Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-desoxysphinganine 1-phosphonate | competitive inhibitor | Homo sapiens | |
1-desoxysphinganine 1-phosphonate | competitive inhibitor | Mus musculus | |
1-desoxysphinganine 1-phosphonate | competitive inhibitor | Rattus norvegicus | |
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-imidazole | - |
Homo sapiens | |
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-imidazole | - |
Mus musculus | |
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-imidazole | - |
Rattus norvegicus | |
2-vinyl dihydrosphingosine | - |
Homo sapiens | |
2-vinyl dihydrosphingosine | - |
Mus musculus | |
2-vinyl dihydrosphingosine | - |
Rattus norvegicus | |
4'-deoxypyridoxine | a pyridoxal 5'-phosphate analog | Homo sapiens | |
4'-deoxypyridoxine | a pyridoxal 5'-phosphate analog | Mus musculus | |
4'-deoxypyridoxine | a pyridoxal 5-phosphate analog | Rattus norvegicus | |
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopentenyl)ethyl]octanamide | - |
Homo sapiens | |
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopentenyl)ethyl]octanamide | - |
Mus musculus | |
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopentenyl)ethyl]octanamide | - |
Rattus norvegicus | |
[2-amino-2[2-(4-octylphenyl)ethyl]-3-hydroxypropyl]dihydrogen phosphate | - |
Homo sapiens | |
[2-amino-2[2-(4-octylphenyl)ethyl]-3-hydroxypropyl]dihydrogen phosphate | - |
Mus musculus | |
[2-amino-2[2-(4-octylphenyl)ethyl]-3-hydroxypropyl]dihydrogen phosphate | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
mitochondrial membrane | - |
Homo sapiens | 31966 | - |
mitochondrial membrane | - |
Mus musculus | 31966 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | Q8R0X7 | - |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
glycoprotein | - |
Mus musculus |
nitrosylation | nitrosylation on tyrosine residues Y356 and Y366 | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | low expression | Mus musculus | - |
colon | high expression | Mus musculus | - |
harderian gland | high expression | Mus musculus | - |
heart | low expression | Mus musculus | - |
HEK-293 cell | - |
Homo sapiens | - |
kidney | moderate expression | Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | moderate expression | Mus musculus | - |
lung | moderate expression | Mus musculus | - |
olfactory epithelium | the enzyme is highly enriched in olfactory mucosal epithelium | Mus musculus | - |
skeletal muscle | low expression | Mus musculus | - |
small intestine | high expression | Mus musculus | - |
spleen | high expression | Mus musculus | - |
stomach | moderate expression | Mus musculus | - |
testis | moderate expression | Mus musculus | - |
thymus | high expression | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-nitrobenz-2-oxa-1,3-diazole-sphingosine 1-phosphate | - |
Homo sapiens | phosphoethanolamine + 7-nitrobenz-2-oxa-1,3-diazole-hexadec-2-enal | - |
? | |
7-nitrobenz-2-oxa-1,3-diazole-sphingosine 1-phosphate | - |
Rattus norvegicus | phosphoethanolamine + 7-nitrobenz-2-oxa-1,3-diazole-hexadec-2-enal | - |
? | |
7-nitrobenz-2-oxa-1,3-diazole-sphingosine 1-phosphate | - |
Mus musculus | phosphoethanolamine + 7-nitrobenz-2-oxa-1,3-diazole-hexadec-2-enal | - |
? | |
boron dipyrromethene difluoride-sphingosine 1-phosphate | - |
Homo sapiens | phosphoethanolamine + boron dipyrromethene difluoride-hexadec-2-enal | - |
? | |
boron dipyrromethene difluoride-sphingosine 1-phosphate | - |
Rattus norvegicus | phosphoethanolamine + boron dipyrromethene difluoride-hexadec-2-enal | - |
? | |
boron dipyrromethene difluoride-sphingosine 1-phosphate | - |
Mus musculus | phosphoethanolamine + boron dipyrromethene difluoride-hexadec-2-enal | - |
? | |
D-(+)-erythro-sphingosine 1-phosphate | - |
Homo sapiens | phosphoethanolamine + (2E)-hexadecenal | - |
ir | |
D-(+)-erythro-sphingosine 1-phosphate | - |
Rattus norvegicus | phosphoethanolamine + (2E)-hexadecenal | - |
ir | |
D-(+)-erythro-sphingosine 1-phosphate | - |
Mus musculus | phosphoethanolamine + (2E)-hexadecenal | - |
ir | |
umbelliferone-labled sphinganine 1-phosphate | - |
Homo sapiens | phosphoethanolamine + 3-[(2-oxo-2H-chromen-7-yl)oxy]propanal | - |
? | |
umbelliferone-labled sphinganine 1-phosphate | - |
Rattus norvegicus | phosphoethanolamine + 3-[(2-oxo-2H-chromen-7-yl)oxy]propanal | - |
? | |
umbelliferone-labled sphinganine 1-phosphate | - |
Mus musculus | phosphoethanolamine + 3-[(2-oxo-2H-chromen-7-yl)oxy]propanal | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer or hexamer | - |
Homo sapiens |
tetramer or hexamer | - |
Rattus norvegicus |
tetramer or hexamer | - |
Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
dihydrosphingosine phosphate lyase | - |
Homo sapiens |
dihydrosphingosine phosphate lyase | - |
Rattus norvegicus |
dihydrosphingosine phosphate lyase | - |
Mus musculus |
Dpl1 | - |
Homo sapiens |
Dpl1 | - |
Rattus norvegicus |
Dpl1 | - |
Mus musculus |
S1P lyase | - |
Homo sapiens |
S1P lyase | - |
Rattus norvegicus |
S1P lyase | - |
Mus musculus |
sphingosine 1-phosphate lyase | - |
Homo sapiens |
sphingosine 1-phosphate lyase | - |
Rattus norvegicus |
sphingosine 1-phosphate lyase | - |
Mus musculus |
SPL | - |
Homo sapiens |
SPL | - |
Rattus norvegicus |
SPL | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | dependent on | Homo sapiens | |
pyridoxal 5'-phosphate | dependent on | Rattus norvegicus | |
pyridoxal 5'-phosphate | dependent on | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | SPL is the final enzyme in the sphingolipid degradative pathway and an important regulator of sphingosine 1-phosphate as well as the levels of other sphingolipid intermediates which influence various aspects of cell growth, proliferation and death. SPL is necessary for maintaining lipid homeostasis and appropriate cell fate responses. SPL serves as a therapeutic target for immune modulation | Homo sapiens |
physiological function | SPL is the final enzyme in the sphingolipid degradative pathway and an important regulator of sphingosine 1-phosphate as well as the levels of other sphingolipid intermediates which influence various aspects of cell growth, proliferation and death. SPL is necessary for maintaining lipid homeostasis and appropriate cell fate responses. SPL serves as a therapeutic target for immune modulation | Rattus norvegicus |
physiological function | SPL is the final enzyme in the sphingolipid degradative pathway and an important regulator of sphingosine 1-phosphate as well as the levels of other sphingolipid intermediates which influence various aspects of cell growth, proliferation and death. SPL is necessary for maintaining lipid homeostasis and appropriate cell fate responses. SPL serves as a therapeutic target for immune modulation | Mus musculus |